The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab55761 purity: > 90%, by SDS-PAGE and visualised by silver stain.
Endotoxin level: < 0.1 ng per µg of FGFR4+Fc
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
ReconstitutionThis protein is soluble in water and most aqueous buffers. The lyophilised
FGFR4+Fc should be reconstituted in PBS or medium to a concentration not lower than 50 µg/ml.
Fibroblast growth factor receptor 4
Hydroxyaryl protein kinase
Protein tyrosine kinase
Tyrosine kinase related to fibroblast growth factor receptor
FunctionReceptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.
Tissue specificityExpressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
Post-translational modificationsGlycosylated. Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization.
Cellular localizationMembrane. Isoform 2 may be secreted.