• NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman


Our Abpromise guarantee covers the use of ab60854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


    Functional Studies

  • FormLiquid
  • Additional notes

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • c fgr
    • c fgr protooncogene
    • c src 2 proto oncogene
    • c src2
    • Fgr
    • FLJ43153
    • Gardner Rasheed feline sarcoma viral (v fgr)
    • Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog
    • Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
    • MGC75096
    • p55 c fgr protein
    • P55 FGR
    • P55-FGR
    • p55c fgr
    • p58-Fgr
    • p58c fgr
    • p58c-Fgr
    • Proto oncogene c Fgr
    • Proto oncogene tyrosine protein kinase FGR
    • Proto-oncogene c-Fgr
    • SRC 2
    • SRC2
    • Tyrosine protein kinase Fgr
    • Tyrosine-protein kinase Fgr
    see all
  • FunctionNon-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
  • Tissue specificityDetected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
  • Involvement in diseaseMutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Post-translational
    Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation.
    Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
  • Cellular localizationCell membrane. Cell membrane. Cell projection > ruffle membrane. Cytoplasm > cytosol. Cytoplasm > cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space. Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts.
  • Information by UniProt

Recombinant human FGR protein images

  • Sample Kinase Activity Plot.
  • ab60854 on SDS-PAGE, MW ~86 kDa.

References for Recombinant human FGR protein (ab60854)

ab60854 has not yet been referenced specifically in any publications.

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