The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
pH: 7.50 Constituents: 20% Glycerol, Tris acetate, 0.03% EDTA
170 kDa melanoma membrane bound gelatinase
170 kDa melanoma membrane-bound gelatinase
Fibroblast activation protein alpha
Integral membrane serine protease
FunctionIn association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.
Tissue specificityFibroblast specific.
Sequence similaritiesBelongs to the peptidase S9B family.
Post-translational modificationsN-glycosylated. The N-terminus may be blocked.
Cellular localizationCell membrane. Cell projection > lamellipodium membrane. Cell projection > invadopodium membrane. Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma.