Recombinant human FKBP12 protein (ab167985)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF VELLKLE
    • Molecular weight
      14 kDa including tags
    • Amino acids
      1 to 108
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167985 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1 µmole of FKBP12 per minute at 25°C in Tris HCl pH8.0 using chymotrypsin.
  • Applications

    SDS-PAGE

    Functional Studies

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 12 kDa FK506-binding protein
    • 12 kDa FKBP
    • Calstabin 1
    • FK506 binding protein 1
    • FK506 binding protein 12
    • FK506 binding protein 1A
    • FK506 binding protein 1A (12kD)
    • FK506 binding protein 1A 12kDa
    • FK506 binding protein T cell 12 kD
    • FK506 binding protein, T cell, 12 kD
    • FK506 binding protein12
    • FK506-binding protein 1A
    • FKB1A_HUMAN
    • FKBP 12
    • FKBP 1A
    • FKBP-12
    • FKBP-1A
    • FKBP1
    • FKBP12
    • FKBP12 Exip3
    • FKBP12C
    • fkbp1a
    • Immunophilin FKBP12
    • Peptidyl prolyl cis trans isomerase
    • Peptidyl-prolyl cis-trans isomerase FKBP1A
    • PKC12
    • PKCI2
    • PPIase
    • PPIase FKBP1A
    • Protein kinase C inhibitor 2
    • Rotamase
    see all
  • Function
    May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • Sequence similarities
    Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
    Contains 1 PPIase FKBP-type domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab167985 (3 µg).

References

ab167985 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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