Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab83482 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab83482 is purified through a Ni2+affinity chromatography followed by gel filtration.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 1mM Sodium Azide
    Constituents: 50mM HEPES, 150mM Sodium chloride, 0.5mM EDTA, pH 8.0

General Info

  • Alternative names
    • 12 kDa FK506-binding protein
    • 12 kDa FKBP
    • Calstabin 1
    • FK506 binding protein 1
    • FK506 binding protein 12
    • FK506 binding protein 1A
    • FK506 binding protein 1A (12kD)
    • FK506 binding protein 1A 12kDa
    • FK506 binding protein T cell 12 kD
    • FK506 binding protein, T cell, 12 kD
    • FK506 binding protein12
    • FK506-binding protein 1A
    • FKB1A_HUMAN
    • FKBP 12
    • FKBP 1A
    • FKBP-12
    • FKBP-1A
    • FKBP1
    • FKBP12
    • FKBP12 Exip3
    • FKBP12C
    • fkbp1a
    • Immunophilin FKBP12
    • Peptidyl prolyl cis trans isomerase
    • Peptidyl-prolyl cis-trans isomerase FKBP1A
    • PKC12
    • PKCI2
    • PPIase
    • PPIase FKBP1A
    • Protein kinase C inhibitor 2
    • Rotamase
    see all
  • FunctionMay play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • Sequence similaritiesBelongs to the FKBP-type PPIase family. FKBP1 subfamily.
    Contains 1 PPIase FKBP-type domain.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Recombinant Human FKBP12 protein (ab83482)

ab83482 has not yet been referenced specifically in any publications.

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