Recombinant human FKBP1B protein (ab167994)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE
    • Molecular weight
      14 kDa including tags
    • Amino acids
      1 to 108
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167994 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1 µmole of suc-AAFP-pNA per minute at 25°C in Tris HCl pH 8.0 using chymotrypsin.
  • Applications

    SDS-PAGE

    Functional Studies

  • Purity
    >90% by SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 12.6 kDa FK506-binding protein
    • 12.6 kDa FKBP
    • Calstabin 2
    • FK506 binding protein 1 like
    • FK506 binding protein 12.6
    • FK506 binding protein 1B
    • FK506 binding protein 1B 12.6 kDa
    • FK506-binding protein 1B
    • FKB1B_HUMAN
    • FKBP 12.6
    • FKBP 1B
    • FKBP 1L
    • FKBP 9
    • FKBP-12.6
    • FKBP-1B
    • FKBP12.6
    • Fkbp1b
    • FKBP1L
    • FKBP9
    • h FKBP 12
    • h-FKBP-12
    • Immunophilin FKBP12.6
    • OTK 4
    • OTK4
    • Peptidyl prolyl cis trans isomerase
    • Peptidyl prolyl cis trans isomerase 1B
    • Peptidyl-prolyl cis-trans isomerase FKBP1B
    • PKBP 1L
    • PKBP1L
    • PPIase
    • PPIase 1B
    • PPIase FKBP1B
    • Rotamase
    • Rotamase 1B
    see all
  • Function
    Associates with the ryanodine receptor (RYR-2) in cardiac muscle sarcoplasmic reticulum and may play a unique physiological role in excitation-contraction coupling in cardiac muscle. There are four molecules of FKBP12.6 per heart muscle RYR. Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • Tissue specificity
    Isoform 1 and isoform 2 are Ubiquitous with highest levels in brain and thymus.
  • Sequence similarities
    Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
    Contains 1 PPIase FKBP-type domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab167994 (3 µg).

References

ab167994 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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