Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Widely expressed. Highest levels seen in the brain.
SDS-PAGE - FKBP38 protein (Tagged-His Tag) (ab93970)
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 46 kDa (purple). The protein-specific band is blue.
has not yet been referenced specifically in any publications.
Publishing research using ab93970? Please let us know so that we can cite the reference in this datasheet.
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