Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      LSELPPLEDMGQPPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILG NGLLRKKTLVPGPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFT LG DCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGSRSPYIPPHAA LCLE VTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLAA NSYDLA IKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYR AALRSCSL VLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEP SNKTIHAELS KLVKKHAAQRSTETALYRKMLGNPSRLPAKCPGKGAWS IPWKWLFGATAV ALGGVALSVVIAARN
    • Amino acids
      49 to 413

Specifications

Our Abpromise guarantee covers the use of ab93970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -80°C.

    Preservative: None
    Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5

  • Reconstitution
    Reconstitution with 95 µl aqua dest.

General Info

  • Alternative names
    • 38 kDa FK506-binding protein
    • 38 kDa FKBP
    • 38kDa
    • FK506 binding protein 8
    • FK506 binding protein 8, 38kDa
    • FK506 binding protein, 38kDa
    • FK506-binding protein 8
    • FKBP 38
    • FKBP-38
    • FKBP-8
    • Fkbp8
    • FKBP8_HUMAN
    • FKBPR38
    • hFKBP38
    • Peptidyl-prolyl cis-trans isomerase FKBP8
    • PPIase FKBP8
    • Rotamase
    • Sam11
    see all
  • Function
    Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
  • Tissue specificity
    Widely expressed. Highest levels seen in the brain.
  • Sequence similarities
    Contains 1 PPIase FKBP-type domain.
    Contains 3 TPR repeats.
  • Cellular localization
    Mitochondrion membrane.
  • Information by UniProt

Images

  • The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 46 kDa (purple). The protein-specific band is blue.

References

ab93970 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab93970.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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