The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Krueppel like factor 11
Krueppel-like factor 11
Krueppel-like transcription factor 1
TGFB Early Growth Response 2
TGFB-inducible early growth response protein 2
TGFB-inducible early growth response protein 2b
TGFB-inducible early growth response protein 3
Transforming Growth Factor Beta Inducible Early Growth Response 2
Transforming growth factor-beta-inducible early growth response protein 2
Transforming growth factor-beta-inducible early growth response protein 3
Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
Ubiquitous. Higher expression in erythroid cells.
Involvement in disease
Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.