Overview

  • Product nameRecombinant Human FLAP protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP20292
    • SpeciesHuman
    • SequenceMDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAF ERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVG YLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTI STTISPLLLIP
    • Molecular weight43 kDa including tags
    • Amino acids1 to 161

Specifications

Our Abpromise guarantee covers the use of ab114639 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 5-lipoxygenase activating protein
    • AL5AP_HUMAN
    • ALOX 5AP
    • ALOX5 AP
    • ALOX5AP
    • Arachidonate 5 lipoxygenase activating protein
    • Arachidonate 5-lipoxygenase-activating protein
    • Five lipoxygenase activating protein
    • FLAP
    • MK 886 binding protein
    • MK-886-binding protein
    see all
  • FunctionRequired for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
  • Involvement in diseaseGenetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
  • Sequence similaritiesBelongs to the MAPEG family.
  • DomainThe C-terminal part after residue 140 is mostly unstructured.
  • Cellular localizationNucleus membrane. Endoplasmic reticulum membrane.
  • Information by UniProt

Recombinant Human FLAP protein images

  • 12.5% SDS-PAGE image showing ab114639 Stained with Coomassie Blue.

References for Recombinant Human FLAP protein (ab114639)

ab114639 has not yet been referenced specifically in any publications.

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