The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% Proprietary Purification.
Protein concentration is above or equal to 0.05 µg/µl.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Dimethylaniline monooxygenase [N oxide forming] 3
Dimethylaniline monooxygenase [N-oxide-forming] 3
Dimethylaniline monooxygenase 3
Dimethylaniline oxidase 3
Flavin containing monooxygenase 3
FMO form 2
Hepatic flavin containing monooxygenase 3
Hepatic flavin-containing monooxygenase 3
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds.
Involvement in disease
Defects in FMO3 are the cause of trimethylaminuria (TMAU) [MIM:602079]; also known as fish-odor syndrome. TMAU is an inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Such individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine.