This product is an active protein and may elicit a biological response in vivo, handle with caution.
Adenylate cyclase-inhibiting G alpha protein
Formyl peptide receptor 1
Guanine nucleotide-binding protein G(i) subunit alpha-2
Lipoxin A4 receptor
N-formyl peptide receptor
N-formylpeptide chemoattractant receptor
RelevanceFMLP (Formyl peptide receptor 1), a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FMLP, attract polymorphonuclear neutrophils to sites of infection. FMLP receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for an FMLP receptor may be able to inhibit HIV infection. FMLP has been reported in blood monocytes, neutrophils, and phagocytes, as well as in liver, astrocytes, and microglia. ESTs have been isolated from B-cell/lung/testis, blood, brain, eye, heart, liver/spleen, kidney, lung, pancreas, placenta, spleen, and uterus libraries.
The G protein family of signal transducers includes 5 heterotrimers, which are most clearly distinguished by their different alpha chains; they have virtually identical beta chains and similar gamma chains. G protein alpha inhibitor chain 2 is a subunit of the G(i) G protein, whose role is in inhibiting adenylate cyclase activity in response to bound GTP. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.