Recombinant Human Frizzled 7 protein (ab112378)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionO75084
    • SpeciesHuman
    • SequenceGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRP AFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFA
    • Molecular weight37 kDa including tags
    • Amino acids155 to 253

Specifications

Our Abpromise guarantee covers the use of ab112378 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThis product is useful for Antibody Production and Protein Array
  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Additional notesab112378 is best used within three months from the date of receipt.This product is useful for Antibody Production and Protein Array
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

General Info

  • Alternative names
    • Frizzled 7, seven transmembrane spanning receptor
    • frizzled class receptor 7
    • Frizzled drosophila homolog of 7
    • Frizzled family receptor 7
    • Frizzled homolog 7
    • Frizzled-7
    • Frizzled7
    • Fz 7
    • Fz-7
    • Fz7
    • FZD 7
    • FZD7
    • FZD7_HUMAN
    • FzE 3
    • FzE3
    • hFz 7
    • hFz7
    • Homolog of Drosophila Frizzled 7
    • OTTHUMP00000163742
    see all
  • FunctionReceptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
  • Tissue specificityHigh expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
  • Sequence similaritiesBelongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • DomainLys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant Human Frizzled 7 protein images

  • ab112378 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

References for Recombinant Human Frizzled 7 protein (ab112378)

ab112378 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112378.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"