This product is an active protein and may elicit a biological response in vivo, handle with caution.
Beta cell Src homology tyrosine kinase
Frk fyn related kinase
FYN related kinase
Gastrointestinal associated kinase
Gastrointestinal associated tyrosine kinase
GTK, mouse, homolog of
Intestine tyrosine kinase
Nuclear tyrosine protein kinase RAK
Protein-tyrosine kinase 5
PTK5 protein tyrosine kinase 5
Tyrosine protein kinase FRK
Tyrosine-protein kinase FRK
FunctionPositively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Tissue specificityRestricted to cells lines derived from tissues of lymphoid, brain, breast, colon and bladder origin.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.