The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesBest to use within three months from the date of receipt of this protein.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced.
FGFR signaling adaptor SNT
FGFR signalling adaptor
FGFR substrate 2
FGFR-signaling adaptor SNT
Fibroblast growth factor receptor substrate 2
Suc 1 Associated Neurotrophic Factor Target
Suc1 associated neurotrophic factor target 1
Suc1-associated neurotrophic factor target 1
FunctionAdapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Tissue specificityHighly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
Post-translational modificationsPhosphorylated on tyrosine residues upon stimulation by NGF. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.