Recombinant Human Fructose 6 Phosphate Kinase protein (ab116487)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP08237
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NAAVRAVVRV GIFTGARVFF VHEGYQGLVD GGDHIKEATW ESVSMMLQLG GTVIGSARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG SLTGADTFRS EWSDLLSDLQ KAGKITDEEA TKSSYLNIVG LVGSIDNDFC GTDMTIGTDS ALHRIMEIVD AITTTAQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE EHLCRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ RGGTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSG NQAVRLPLME CVQVTKDVTK AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVAVMNVGA PAAGMNAAVR STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGWSYVGGWT GQGGSKLGTK RTLPKKSFEQ ISANITKFNI QGLVIIGGFE AYTGGLELME GRKQFDELCI PFVVIPATVS NNVPGSDFSV GADTALNTIC TTCDRIKQSA AGTKRRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF TIRDLQANVE HLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG HMQQGGSPTP FDRNFATKMG AKAMNWMSGK IKESYRNGRI FANTPDSGCV LGMRKRALVF QPVAELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV
    • Molecular weight87 kDa including tags
    • Amino acids1 to 780
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab116487 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 80 % SDS-PAGE.
    ab116487 was purified by standard chromatographic techniques and filter sterilized.
  • FormLiquid
  • Additional notesalthough stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.08% DTT, 1.17% Sodium chloride, 20% Glycerol

General Info

  • Alternative names
    • 6 Phosphofructokinase Muscle Type
    • 6-phosphofructokinase
    • 6-phosphofructokinase muscle type
    • EC 2.7.1.1
    • EC 2.7.1.11
    • GSD7
    • K6PF_HUMAN
    • MGC8699
    • muscle type
    • PFK, muscle type
    • PFK-A
    • PFKA
    • PFKL
    • PFKM
    • PFKP
    • PFKX
    • Phosphofructo 1 Kinase Isozyme A
    • Phosphofructo-1-kinase isozyme A
    • Phosphofructokinase 1
    • Phosphofructokinase M
    • Phosphofructokinase, muscle
    • Phosphofructokinase, muscle type
    • Phosphofructokinase, polypeptide X
    • Phosphofructokinase-M
    • Phosphohexokinase
    see all
  • PathwayCarbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
  • Involvement in diseaseDefects in PFKM are the cause of glycogen storage disease type 7 (GSD7) [MIM:232800]; also known as Tarui disease. GSD7 is an autosomal recessive disorder characterized by exercise intolerance with associated nausea and vomiting. Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after vigorous exercise. Most patients obtain a "second wind" when the onset of exercise is followed by a brief rest period. In time patients adjust their activity level and are well compensated.
  • Sequence similaritiesBelongs to the phosphofructokinase family. Two domains subfamily.
  • Information by UniProt

References for Recombinant Human Fructose 6 Phosphate Kinase protein (ab116487)

ab116487 has not yet been referenced specifically in any publications.

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