Recombinant Human GADD45GIP1 protein (ab113863)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ8TAE8
    • SpeciesHuman
    • SequenceMGSSHHHHHHSSGLVPRGSHMPRWQLGPRYAAKQFARYGAASGVVPGSLW PSPEQLRELEAEEREWYPSLATMQESLRVKQLAEEQKRREREQHIAECMA KMPQMIVNWQQQQRENWEKAQADKERRARLQAEAQELLGYQVDPRSARFQ ELLQDLEKKERKRLKEEKQKRKKEARAAALAAAVAQDPAASGAPSS
    • Molecular weight23 kDa including tags
    • Amino acids48 to 222
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab113863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity> 90 % SDS-PAGE.
    ab113863 was purified by using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 40% Glycerol, 0.03% DTT, 1.17% Sodium chloride

General Info

  • Alternative names
    • 39S ribosomal protein L59 mitochondrial
    • CKBBP2
    • CKbetaBP2
    • CKII beta associating protein
    • CKII beta binding protein 2
    • CKII beta-associating protein
    • CR6 interacting factor 1
    • CR6-interacting factor 1
    • CRIF1
    • G45IP_HUMAN
    • Gadd45gip1
    • Growth arrest and DNA damage inducible GADD45G interacting protein
    • growth arrest and DNA damage inducible, gamma interacting protein 1
    • Growth arrest and DNA damage-inducible proteins-interacting protein 1
    • MGC4667
    • MGC4758
    • MRP L59
    • p53 responsive gene 6
    • p53 responsive gene 6 protein
    • p53-responsive gene 6 protein
    • Papillomavirus L2 interacting nuclear protein 1
    • Papillomavirus L2-interacting nuclear protein 1
    • PLINP
    • PLINP 1
    • PLINP-1
    • PLINP1
    • PRG6
    see all
  • FunctionActs as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
  • Tissue specificityWidely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.
  • Cellular localizationNucleus.
  • Information by UniProt

Recombinant Human GADD45GIP1 protein images

  • ab113863 at 3 µg analysed by 15% SDS-PAGE.

References for Recombinant Human GADD45GIP1 protein (ab113863)

ab113863 has not yet been referenced specifically in any publications.

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