Recombinant Human GALNT1 protein (ab117035)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionQ10472-2
    • SpeciesHuman
    • SequenceMRKFAYCKVVLATSLIWVLLDMFLLLYFSECNKCDEKKERGLPAGDVLEP VQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPD VRLEG
    • Molecular weight38 kDa including tags
    • Amino acids1 to 105

Associated products

Specifications

Our Abpromise guarantee covers the use of ab117035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • GALNAC T1
    • GalNAc transferase 1
    • GalNAc-T1
    • GALNT 1
    • GALNT1
    • GALT1_HUMAN
    • Polypeptide GalNAc transferase 1
    • Polypeptide N acetylgalactosaminyltransferase 1
    • Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
    • pp GaNTase 1
    • pp-GaNTase 1
    • Protein UDP acetylgalactosaminyltransferase 1
    • Protein-UDP acetylgalactosaminyltransferase 1
    • UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 1
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1 (GalNAc T1)
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1
    see all
  • FunctionCatalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.
  • Tissue specificityWidely expressed. Expressed in all tissues tested.
  • PathwayProtein modification; protein glycosylation.
  • Sequence similaritiesBelongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • DomainThere are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates.
  • Cellular localizationSecreted and Golgi apparatus > Golgi stack membrane.
  • Information by UniProt

Recombinant Human GALNT1 protein images

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab117035 at approximately 37.62 kDa.

References for Recombinant Human GALNT1 protein (ab117035)

ab117035 has not yet been referenced specifically in any publications.

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