The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Beta glucocerebrosidase 2
Beta glucosidase 2
glucosidase, beta (bile acid) 2
Non lysosomal glucosylceramidase
GBA2 is a non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. It is involved in sphingomyelin generation and prevention of glycolipid accumulation. GBA2 may also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo.
Cell membrane; Single-pass membrane protein. Note=Not localized to lipid rafts.
ab163631 on a 12.5% SDS-PAGE stained with Coomassie Blue.
This product has been referenced in:
Berger Z et al. Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates. PLoS One10:e0119141 (2015).
Read more (PubMed: 25763858) »