Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab40570 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.002% Sodium Azide
    Constituents: 3mM Sodium chloride, 2.5mM Imidazole, 10mM Tris, pH 8.0

General Info

  • Alternative names
    • DNA replication inhibitor
    • Gem
    • GEMI_HUMAN
    • Geminin
    • Geminin DNA replication inhibitor
    • GMNN
    • OTTHUMP00000039393
    • RP3 369A17.3
    see all
  • Function
    Inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
  • Sequence similarities
    Belongs to the geminin family.
  • Developmental stage
    Absent during G1 phase, accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition.
  • Information by UniProt

Images

  • Analysis of GMNN (Geminin) Recombinant Protein (1µg).
    4-20% SDS gradient gel. Coomassie blue staining.

References

ab40570 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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