This product is an active protein and may elicit a biological response in vivo, handle with caution.
B lymphocyte serine/threonine protein kinase
B lymphocyte serine/threonine-protein kinase
Germinal center kinase
germinal centre kinase (GC kinase)
MAPK/ERK kinase kinase kinase 2
MEK kinase kinase 2
Mitogen activated protein kinase kinase kinase kinase 2
Mitogen-activated protein kinase kinase kinase kinase 2
Rab8 interacting protein
Rab8 interacting protein, formerly
FunctionEnhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion.
Tissue specificityHighly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CNH domain. Contains 1 protein kinase domain.