Recombinant Human Glutamyl hydrolase gamma protein (ab123172)

Overview

  • Product nameRecombinant Human Glutamyl hydrolase gamma protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ92820
    • SpeciesHuman
    • SequenceMGSSHHHHHHSSGLVPRGSHMRPHGDTAKKPIIGILMQKCRNKVMKNYGR YYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLR RSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTAT DTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKN FTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWK NLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPI YTGNISSFQQCYIFD
    • Molecular weight36 kDa including tags
    • Amino acids25 to 318
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123172 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity> 95 % SDS-PAGE.
    ab123172 is purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • Conjugase
    • folylpolygammaglutamyl hydrolase
    • gamma glutamyl hydrolase
    • Gamma-Glu-X carboxypeptidase
    • Gamma-glutamyl hydrolase
    • Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
    • GGH
    • GGH_HUMAN
    • gH
    see all
  • FunctionHydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
  • Sequence similaritiesBelongs to the peptidase C26 family.
    Contains 1 gamma-glutamyl hydrolase domain.
  • Cellular localizationSecreted > extracellular space. Lysosome. Melanosome. While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

Recombinant Human Glutamyl hydrolase gamma protein images

  • 15% SDS-PAGE showing ab123172 at approximately 35.9 kDa (3µg loaded).

References for Recombinant Human Glutamyl hydrolase gamma protein (ab123172)

ab123172 has not yet been referenced specifically in any publications.

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