Recombinant Human Glutaredoxin 5 protein (ab117649)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MSGSLGRAAA ALLRWGRGAG GGGLWGPGVR AAGSGAGGGG SAEQLDALVK KDKVVVFLKG TPEQPQCGFS NAVVQILRLH GVRDYAAYNV LDDPELRQGI KDYSNWPTIP QVYLNGEFVG GCDILLQMHQ NGDLVEELKK LGIHSALLDE KKDQDSK
    • Molecular weight
      19 kDa including tags
    • Amino acids
      1 to 157
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab117649 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 85 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 20% Glycerol

General Info

  • Alternative names
    • C14orf87
    • Chromosome 14 open reading frame 87
    • FLB4739
    • GLRX 5
    • Glrx5
    • GLRX5_HUMAN
    • Glutaredoxin 5 homolog
    • Glutaredoxin related protein 5
    • Glutaredoxin-related protein 5
    • Glutaredoxin5
    • GRX5
    • MGC14129
    • mitochondrial
    • Monothiol glutaredoxin-5
    • PRO1238
    see all
  • Function
    Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
  • Involvement in disease
    Defects in GLRX5 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA) [MIM:205950]. A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus.
  • Sequence similarities
    Belongs to the glutaredoxin family. Monothiol subfamily.
    Contains 1 glutaredoxin domain.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt

References for Recombinant Human Glutaredoxin 5 protein (ab117649)

ab117649 has not yet been referenced specifically in any publications.

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