Recombinant Human Glypican 3 protein (ab114311)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP51654
    • SpeciesHuman
    • SequenceHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNEL FDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVS
    • Molecular weight37 kDa including tags
    • Amino acids121 to 220

Specifications

Our Abpromise guarantee covers the use of ab114311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • DGSX
    • Glypican proteoglycan 3
    • Glypican-3 [Precursor]
    • Gpc3
    • GPC3_HUMAN
    • GTR2 2
    • GTR2-2
    • Heparan sulphate proteoglycan
    • Intestinal protein OCI 5
    • Intestinal protein OCI-5
    • MXR7
    • OCI 5
    • OCI-5
    • OCI5
    • SDYS
    • Secreted glypican-3
    • SGB
    • SGBS
    • SGBS1
    see all
  • FunctionCell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
  • Tissue specificityHighly expressed in lung, liver and kidney.
  • Involvement in diseaseDefects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.
  • Sequence similaritiesBelongs to the glypican family.
  • Cellular localizationCell membrane and Secreted > extracellular space.
  • Information by UniProt

Recombinant Human Glypican 3 protein images

  • SDS-PAGE analysis of ab114311 on a 12.5% gel stained with Coomassie Blue.

References for Recombinant Human Glypican 3 protein (ab114311)

ab114311 has not yet been referenced specifically in any publications.

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