Recombinant Human GMP Synthase protein (ab123202)

Overview

  • Product nameRecombinant Human GMP Synthase protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP49915
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MGSHMALCNG DSKLENAGGD LKDGHHHYEG AVVILDAGAQ YGKVIDRRVR ELFVQSEIFP LETPAFAIKE QGFRAIIISG GPNSVYAEDA PWFDPAIFTI GKPVLGICYG MQMMNKVFGG TVHKKSVRED GVFNISVDNT CSLFRGLQKE EVVLLTHGDS VDKVADGFKV VARSGNIVAG IANESKKLYG AQFHPEVGLT ENGKVILKNF LYDIAGCSGT FTVQNRELEC IREIKERVGT SKVLVLLSGG VDSTVCTALL NRALNQEQVI AVHIDNGFMR KRESQSVEEA LKKLGIQVKV INAAHSFYNG TTTLPISDED RTPRKRISKT LNMTTSPEEK RKIIGDTFVK IANEVIGEMN LKPEEVFLAQ GTLRPDLIES ASLVASGKAE LIKTHHNDTE LIRKLREEGK VIEPLKDFHK DEVRILGREL GLPEELVSRH PFPGPGLAIR VICAEEPYIC KDFPETNNIL KIVADFSASV KKPHTLLQRV KACTTEEDQE KLMQITSLHS LNAFLLPIKT VGVQGDCRSY SYVCGISSKD EPDWESLIFL ARLIPRMCHN VNRVVYIFGP PVKEPPTDVT PTFLTTGVLS TLRQADFEAH NILRESGYAG KISQMPVILT PLHFDRDPLQ KQPSCQRSVV IRTFITSDFM TGIPATPGNE IPVEVVLKMV TEIKKIPGIS RIMYDLTSKP PGTTEWE
    • Molecular weight79 kDa including tags
    • Amino acids1 to 693
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123202 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab123202 is purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 30% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • Glutamine amidotransferase
    • GMP synthase [glutamine hydrolyzing]
    • GMP synthase [glutamine-hydrolyzing]
    • GMP synthetase
    • Gmps
    • GUAA_HUMAN
    • Guanine monphosphate synthetase
    • Guanosine 5' monophosphate synthase
    • MLL/GMPS fusion protein
    see all
  • FunctionInvolved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
  • PathwayPurine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
  • Involvement in diseaseNote=A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with MLL.
  • Sequence similaritiesContains 1 glutamine amidotransferase type-1 domain.
    Contains 1 GMP-binding domain.
  • Cellular localizationCytoplasm.
  • Information by UniProt

Recombinant Human GMP Synthase protein images

  • 15% SDS-PAGE showing ab123202 (3µg).

References for Recombinant Human GMP Synthase protein (ab123202)

ab123202 has not yet been referenced specifically in any publications.

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