Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMMEGLVFSRLSPEYYDLARAHLRDEEKSCP CLAQEGPQGDLLTKTQELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATR VCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLRLCIPSTGP LGSHHHHHH
    • Molecular weight
      18 kDa including tags
    • Amino acids
      1 to 130
    • Tags
      His tag N-Terminus
    • Additional sequence information
      GNLY Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 159 amino acids and fused to a double His Tag (N+C terminus).

Specifications

Our Abpromise guarantee covers the use of ab117675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    ab117675 is purified by proprietary chromatographic techniques.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

  • Reconstitution
    It is recommended to reconstitute in sterile Ultra pure water not less than 100µg/ml, which can then be further diluted into other aqueous solutions. Although stable at room temperature for 3 weeks, ab117675 should be stored desiccated below -18°C. Upon reconstitution ab117675 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

General Info

  • Alternative names
    • 519
    • D2S69E
    • GNLY
    • GNLY_HUMAN
    • Granulysin
    • Granulysin precursor
    • LAG 2
    • LAG2
    • Lymphocyte activation gene 2
    • Lymphokine LAG 2
    • Lymphokine LAG-2
    • NKG 5
    • NKG5
    • Protein NKG5
    • T cell activation protein 519
    • T lymphocyte activation gene 519
    • T-cell activation protein 519
    • TLA519
    see all
  • Function
    Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
  • Tissue specificity
    Expressed in natural killer and T-cells.
  • Sequence similarities
    Contains 1 saposin B-type domain.
  • Post-translational
    modifications
    A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.
  • Cellular localization
    Secreted. Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
  • Information by UniProt

References

ab117675 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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