The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
pH: 8.00 Constituents: 0.32% Tris HCl, 20% Glycerol
Glycine N methyltransferase
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Abundant in liver.
Involvement in disease
Defects in GNMT are the cause of glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]; also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.
Belongs to the glycine N-methyltransferase family.