The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
G protein coupled receptor MRGX 2
G protein coupled receptor MRGX2
Mas related G protein coupled receptor member X2
Mas related gene MRGX 2
Mas related gene MRGX2
MAS related GPR member X2
Mas-related G-protein coupled receptor member X
Mas-related G-protein coupled receptor member X2
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.