Recombinant Human Granulin protein (ab108947)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      P28799
    • Species
      Human
    • Molecular weight
      10 kDa including tags
    • Amino acids
      364 to 430
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab108947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    > 90 % SDS-PAGE.
    ab108947 is 0.2µm filtered.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2

General Info

  • Alternative names
    • Acrogranin
    • CLN11
    • GEP
    • GP88
    • Granulin A
    • Granulin B
    • Granulin C
    • Granulin D
    • Granulin E
    • Granulin epithelin
    • Granulin F
    • Granulin G
    • Granulin-7
    • Granulins
    • GRN
    • GRN_HUMAN
    • PC cell derived growth factor
    • PCDGF
    • PEPI
    • PGRN
    • Proepithelin
    • Progranulin
    see all
  • Function
    Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
    Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
  • Tissue specificity
    In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
  • Involvement in disease
    Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.
  • Sequence similarities
    Belongs to the granulin family.
  • Post-translational
    modifications
    Granulins are disulfide bridged.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab108947 has not yet been referenced specifically in any publications.

Publishing research using ab108947? Please let us know so that we can cite the reference in this datasheet.

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