Recombinant Human Granulin protein (ab108947)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP28799
    • SpeciesHuman
    • Molecular weight10 kDa including tags
    • Amino acids364 to 430
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab108947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level< 1.000 Eu/µg
  • Purity> 90 % SDS-PAGE.
    ab108947 is 0.2µm filtered.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2

General Info

  • Alternative names
    • Acrogranin
    • CLN11
    • GEP
    • GP88
    • Granulin A
    • Granulin B
    • Granulin C
    • Granulin D
    • Granulin E
    • Granulin epithelin
    • Granulin F
    • Granulin G
    • Granulin-7
    • Granulins
    • GRN
    • GRN_HUMAN
    • PC cell derived growth factor
    • PCDGF
    • PEPI
    • PGRN
    • Proepithelin
    • Progranulin
    see all
  • FunctionGranulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
    Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
  • Tissue specificityIn myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
  • Involvement in diseaseDefects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.
  • Sequence similaritiesBelongs to the granulin family.
  • Post-translational
    modifications
    Granulins are disulfide bridged.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant Human Granulin protein (ab108947)

ab108947 has not yet been referenced specifically in any publications.

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