The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Cytolytic t cell and natural killer cell specific trypsin like serine protease
Cytotoxic T lymphocyte associated serine esterase 3
Cytotoxic T lymphocyte proteinase 1
Cytotoxic T-lymphocyte proteinase 1
Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3
Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease)
Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3)
Granzyme A precursor
Hanukah factor serine protease
FunctionThis enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis.
Sequence similaritiesBelongs to the peptidase S1 family. Granzyme subfamily. Contains 1 peptidase S1 domain.