The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cathepsin G like 1
Cathepsin G-like 1
Cytotoxic serine protease B
Cytotoxic T lymphocyte associated serine esterase 1
Cytotoxic T lymphocyte proteinase 2
Cytotoxic T-lymphocyte proteinase 2
Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1)
Human lymphocyte protein
Protease, serine, B
T cell serine protease 1-3E
T-cell serine protease 1-3E
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Belongs to the peptidase S1 family. Granzyme subfamily. Contains 1 peptidase S1 domain.
Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.