Epidermal growth factor receptor binding protein GRB2
GRB2 adapter protein
Growth factor receptor bound protein 2
Growth factor receptor bound protein 3
Growth factor receptor-bound protein 2
SH2/SH3 adapter GRB2
FunctionAdapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Sequence similaritiesBelongs to the GRB2/sem-5/DRK family. Contains 1 SH2 domain. Contains 2 SH3 domains.
DomainThe SH3 domains mediate interaction with RALGPS1 and SHB.