Recombinant Human Gremlin 1 protein (ab111462)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionO60565
    • SpeciesHuman
    • SequenceMKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEV LESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCN SFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRV KQCRCISIDLD
    • Molecular weight18 kDa
    • Amino acids25 to 184

Specifications

Our Abpromise guarantee covers the use of ab111462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Constituent: 0.3% Acetic acid

  • ReconstitutionReconstitute in 50mM acetic acid or sterile water to a concentration of 0.1 mg/ml.

General Info

  • Alternative names
    • BMP antagonist 1
    • Cell proliferation inducing gene 2 protein
    • Cell proliferation-inducing gene 2 protein
    • CKTSF1B1
    • colorectal adenoma and carcinoma 1
    • Cysteine knot superfamily 1
    • Cysteine knot superfamily 1, BMP antagonist 1
    • Cysteine knot superfamily BMP antagonist 1
    • DAN domain family member 2
    • DAND2
    • Down regulated in Mos-transformed cells protein
    • Down-regulated in Mos-transformed cells protein
    • DRM
    • grem1
    • GREM1_HUMAN
    • GREMLIN
    • Gremlin 1 homolog, cysteine knot superfamily
    • Gremlin 1 like protein
    • Gremlin 1, cysteine knot superfamily, homolog
    • Gremlin-1
    • Gremlin1
    • IHG-2
    • IHG2
    • Increased in high glucose 2
    • Increased in high glucose protein 2
    • PIG2
    • Proliferation inducing gene 2
    • proliferation inducing gene 2 protein
    see all
  • FunctionCytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.
  • Tissue specificityHighly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts.
  • Involvement in diseasePolyposis syndrome, mixed hereditary 1
  • Sequence similaritiesBelongs to the DAN family.
    Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Cellular localizationSecreted.
  • Information by UniProt

Recombinant Human Gremlin 1 protein images

  • SDS-PAGE analysis of recombinant Human Gremlin 1 (ab111462). Samples were loaded in 15% SDS-polyacrylamide gel and stained with Coomassie blue. Lane 1: unreduced Gremlin 1; Lane 2: reduced Gremlin 1.

References for Recombinant Human Gremlin 1 protein (ab111462)

ab111462 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

The human Gremlin-1 is purified from the inclusion bodies and refolded on the column. So far we do not have verified biological data.

We are happy to provide you 100% Abreview discount in case you are inte...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"