The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThis product is useful for Antibody Production and Protein Array
Additional notesBest use within three months from the date of receiptThis product is useful for Antibody Production and Protein Array
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced.
BMP antagonist 1
Cell proliferation inducing gene 2 protein
Cell proliferation-inducing gene 2 protein
colorectal adenoma and carcinoma 1
Cysteine knot superfamily 1
Cysteine knot superfamily 1, BMP antagonist 1
Cysteine knot superfamily BMP antagonist 1
DAN domain family member 2
Down regulated in Mos-transformed cells protein
Down-regulated in Mos-transformed cells protein
Gremlin 1 homolog, cysteine knot superfamily
Gremlin 1 like protein
Gremlin 1, cysteine knot superfamily, homolog
Increased in high glucose 2
Increased in high glucose protein 2
Proliferation inducing gene 2
proliferation inducing gene 2 protein
FunctionCytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.
Tissue specificityHighly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts.
Involvement in diseasePolyposis syndrome, mixed hereditary 1
Sequence similaritiesBelongs to the DAN family. Contains 1 CTCK (C-terminal cystine knot-like) domain.