Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
Endoplasmic reticulum lumenal Ca2+ binding protein grp78
Epididymis secretory sperm binding protein Li 89n
Glucose Regulated Protein 78kDa
Heat shock 70 kDa protein 5
Heat Shock 70kDa Protein 5
Heat shock protein family A (Hsp70) member 5
HEL S 89n
Immunoglobulin Heavy Chain Binding Protein
Immunoglobulin heavy chain-binding protein
FunctionProbably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.
Involvement in diseaseAutoantigen in rheumatoid arthritis.
Sequence similaritiesBelongs to the heat shock protein 70 family.
Cellular localizationEndoplasmic reticulum lumen. Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.