This product is an active protein and may elicit a biological response in vivo, handle with caution.
germ cell associated 2
Germ cell-specific gene 2 protein
Haploid germ cell-specific nuclear protein kinase
Serine/threonine-protein kinase haspin
FunctionRequired for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis.
Tissue specificityStrongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. Contains 1 protein kinase domain.
Post-translational modificationsAutophosphorylated on both serine and threonine residues (By similarity). Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.