Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      78 to 138

Specifications

Our Abpromise guarantee covers the use of ab90195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.
    Purified by affinity chromatography
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -20ºC. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Bmk
    • Hck
    • Hck 1
    • HCK_HUMAN
    • Hemopoietic cell kinase
    • JTK9
    • p59-HCK/p60-HCK
    • p59Hck
    • p59HCK/p60HCK
    • p61Hck
    • Tyrosine protein kinase HCK
    • Tyrosine-protein kinase HCK
    see all
  • Function
    May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
  • Tissue specificity
    Expressed predominantly in cells of the myeloid and B-lymphoid lineages.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Domain
    The SH3 domain mediates binding to HIV-1 Nef.
  • Cellular localization
    Membrane. Cytoplasm. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated and Membrane. Membrane > caveola. 20% of this isoform is associated with caveolae, this association depends on palmitoylation of cyteine at position 3.
  • Information by UniProt

References

ab90195 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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