Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTE HINIHQLRNKVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVG HEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEKHTSQ KDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGI QKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESMAEEKR KREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLE GLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEV LEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFD PDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
    • Molecular weight
      80 kDa including tags
    • Amino acids
      1 to 486

Associated products

Specifications

Our Abpromise guarantee covers the use of ab116926 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Cortactin like
    • CTTNL
    • HCLS 1
    • Hcls1
    • HCLS1_HUMAN
    • Hematopoietic cell specific Lyn substrate 1
    • Hematopoietic cell-specific LYN substrate 1
    • Hematopoietic lineage cell-specific protein
    • HS 1
    • HS1
    • LckBP1
    • OTTHUMP00000215180
    • OTTHUMP00000215182
    • p75
    see all
  • Function
    Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
  • Tissue specificity
    Expressed only in tissues and cells of hematopoietic origin.
  • Sequence similarities
    Contains 4 cortactin repeats.
    Contains 1 SH3 domain.
  • Developmental stage
    Expressed in early stage of myeloid and erythroid differentiation.
  • Post-translational
    modifications
    Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells.
  • Cellular localization
    Membrane. Cytoplasm. Mitochondrion.
  • Information by UniProt

Recombinant Human HCLS1 protein images

  • 12.5% SDS-PAGE image showing ab116926 at approx 79.53 kDa. Stained with Coomassie Blue.

References for Recombinant Human HCLS1 protein (ab116926)

ab116926 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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