Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      1 to 481
    • Tags
      His tag C-Terminus , GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab80283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific Activity: 1.6 pmol/min/ug. Assay condition : 25 mM Tris/Cl, pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 20 uM BPS HDAC substrate, and 20 ng/ul HDAC10. Incubation condition: 30 min at 37ºC.
  • Applications

    Functional Studies

    SDS-PAGE

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • DKFZP761B039
    • HD 10
    • HD10
    • HDA10_HUMAN
    • HDAC 10
    • Hdac10
    • Histone deacetylase 10
    • MGC149722
    • OTTHUMP00000028555
    see all
  • Function
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
  • Tissue specificity
    Ubiquitous. High expression in liver, spleen, pancreas and kidney.
  • Sequence similarities
    Belongs to the histone deacetylase family. HD type 2 subfamily.
  • Cellular localization
    Cytoplasm. Nucleus. Excluded from the nucleoli.
  • Information by UniProt

Images

  • Image showing specific activity of ab80283.
  • SDS-PAGE showing ab80283 at approximately 79kDa (4µg).

References

ab80283 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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