Recombinant Human HDAC11 protein (ab101113)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus
  • Amino Acid Sequence
    • AccessionQ96DB2
    • SpeciesHuman
    • SequenceMLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLK EEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIF LPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGG GFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYI MDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHL PDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
    • Molecular weight66 kDa including tags
    • Amino acids1 to 347

Specifications

Our Abpromise guarantee covers the use of ab101113 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity52 RLU/min/ng
  • Applications

    Functional Studies

    SDS-PAGE

    Western blot

  • Purity> 75 % SDS-PAGE.
    The purity was determined to be >75% by densitometry
  • FormLiquid
  • Additional notes 52 RLU/min/ng
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

General Info

  • Alternative names
    • FLJ22237
    • HD 11
    • HD11
    • HDA11_HUMAN
    • HDAC 11
    • HDAC11
    • Histone deacetylase 11
    see all
  • FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
  • Tissue specificityWeakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
  • Sequence similaritiesBelongs to the histone deacetylase family.
  • Cellular localizationNucleus. Predominantly nuclear.
  • Information by UniProt

Recombinant Human HDAC11 protein images

  • Anti-HDAC11 antibody (ab87765) at 1 µg/ml + Recombinant Human HDAC11 protein (ab101113) at 0.1 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 1 minute
  • The putity of ab101113 was determined to be >75% by densitometry.

    Approximate MWt: 66kDa
  • The specific activity of ab101113 was determined to be 52 RLU/min/ng.

References for Recombinant Human HDAC11 protein (ab101113)

ab101113 has not yet been referenced specifically in any publications.

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