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Source Escherichia coli
Amino Acid Sequence
Sequence MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY
Molecular weight 12 kDa
Amino acids 1 to 100
Additional sequence information The HDGF Human recombinant protein is a single, non-glycosylated polypeptide chain produced in E. coli, having a molecular weight of 11.5kDa and containing 100 amino acids. Specifications
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity > 95
% SDS-PAGE. Sterile Filtered clear solution
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 10% Glycerol, 0.32% Tris HCl, 0.02% DTT, 0.03% EDTA
Function Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.
Tissue specificity Ubiquitous.
Sequence similarities Belongs to the HDGF family. Contains 1 PWWP domain.
Domain The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured.
Post-translational modifications Sumoylated by SUMO1. Sumoylation prevents binding to chromatin.
Cellular localization Cytoplasm. Nucleus.
Information by UniProt
References for Recombinant Human HDGF protein (ab116408)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"