The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Heparin cofactor 2
Heparin cofactor II
Protease inhibitor leuserpin 2
Protease inhibitor leuserpin-2
serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
Expressed predominantly in liver. Also present in plasma.
Involvement in disease
Thrombophilia due to heparin cofactor 2 deficiency
Belongs to the serpin family.
The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
Phosphorylation sites are present in the extracellular medium.