This product is an active protein and may elicit a biological response in vivo, handle with caution.
Dual specificity phosphatase 1
Hematopoietic protein tyrosine phosphatase
Hematopoietic protein-tyrosine phosphatase
Protein tyrosine phoshatase non receptor type stress induced
Protein tyrosine phoshatase nonreceptor type stress induced
Protein tyrosine phosphatase LC PTP
Protein tyrosine phosphatase non receptor type 7
Protein-tyrosine phosphatase LC-PTP
Tyrosine protein phosphatase non receptor type 7
Tyrosine-protein phosphatase non-receptor type 7
FunctionProtein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Tissue specificityExpressed exclusively in thymus and spleen.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 tyrosine-protein phosphatase domain.
Post-translational modificationsPhosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.