Recombinant Human HEXIM1 protein (ab117163)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionO94992
    • SpeciesHuman
    • SequenceMRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMAE PFLSEYQHQP QTSNCTGAAA VQEELNPERP PGAEERVPEE DSRWQSRAFP QLGGRPGPEG EGSLESQPPP LQTQACPESS CLREGEKGQN GDDSSAGGDF PPPAEVEPTP EAELLAQPCH DSEASKLGAP AAGGEEEWGQ QQRQLGKKKH RRRPSKKKRH WKPYYKLTWE EKKKFDEKQS LRASRIRAEM FAKGQPVAPY NTTQFLMDDH DQEEPDLKTG LYSKRAAAKS DDTSDDDFME EGGEEDGGSD GMGGDGSEFL QRDFSETYER YHTESLQNMS KQELIKEYLE LEKCLSRMED ENNRLRLESK RLGGDDARVR ELELELDRLR AENLQLLTEN ELHRQQERAP LSKFGD
    • Molecular weight45 kDa including tags
    • Amino acids1 to 359
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab117163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab117163 was purified by proprietary chromatographic techniques and filter sterilized.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.58% Sodium chloride, 10% Glycerol, 0.32% Tris HCl

General Info

  • Alternative names
    • Cardiac lineage protein 1
    • CLP 1
    • CLP1
    • EDG 1
    • EDG1
    • Estrogen down-regulated gene 1 protein
    • FLJ13562
    • Hexamethylene bis acetamide inducible 1
    • Hexamethylene bis acetamide inducible protein
    • Hexamethylene bis acetamide inducible transcript 1
    • Hexamethylene bis-acetamide-inducible protein 1
    • HEXI1_HUMAN
    • HEXIM 1
    • Hexim1
    • HEXIM1 protein
    • HIS 1
    • HIS1
    • HMBA inducible
    • MAQ 1
    • MAQ1
    • Menage a quatre 1
    • Menage a quatre protein 1
    • Protein HEXIM1
    see all
  • FunctionTranscriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
  • Tissue specificityUbiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
  • Sequence similaritiesBelongs to the HEXIM family.
  • DomainThe coiled-coil domain mediates oligomerization.
  • Cellular localizationNucleus. Cytoplasm. Binds alpha-importin and is mostly nuclear.
  • Information by UniProt

References for Recombinant Human HEXIM1 protein (ab117163)

ab117163 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab117163.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"