This product is an active protein and may elicit a biological response in vivo, handle with caution.
Homeodomain interacting protein kinase 1
Homeodomain interacting protein kinase 1 like protein
Homeodomain-interacting protein kinase 1
Nuclear body associated kinase 2
Nuclear body associated kinase 2b
FunctionMay play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.
Tissue specificityUbiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.
Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Contains 1 protein kinase domain.
Post-translational modificationsAutophosphorylated. Phosphorylated and activated by JNK1.