This product is an active protein and may elicit a biological response in vivo, handle with caution.
Androgen receptor interacting nuclear protein kinase
Androgen receptor-interacting nuclear protein kinase
Fas interacting serine/threonine protein kinase
Fas-interacting serine/threonine-protein kinase
homeodomain interacting protein kinase 3
Homeodomain-interacting protein kinase 3
Homolog of protein kinase YAK1
FunctionSeems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.
Tissue specificityOverexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Contains 1 protein kinase domain.
Post-translational modificationsAutophosphorylated, but autophosphorylation is not required for catalytic activity. May be sumoylated.