The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
CDNA FLJ10147 fis clone HEMBA1003369
Dermal papilla derived protein 8
Dermal papilla-derived protein 8
Estrogen related receptor beta like 1
Estrogen related receptor beta like protein 1
Estrogen-related receptor beta-like protein 1
Hip1 Interacting protein
HIP1 interacting protein HIPPI
Hip1 protein interactor
Huntingtin interacting protein 1 interacting protein
Huntingtin interacting protein 1 protein interactor
Intraflagellar transport 57 homolog
Intraflagellar transport 57 homolog (Chlamydomonas)
Intraflagellar transport protein 57 homolog
Vestrogen related receptor beta like 1
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).
Belongs to the IFT57 family.
The pseudo DED region (pDED) meadiates the interaction with HIP1.
Cytoplasm > cytoskeleton > cilium basal body. Concentrates within the inner segment of cilia.