Recombinant Human Histamine H2 Receptor - Gqa fusion protein (ab90397)

Overview

  • Product name
    Recombinant Human Histamine H2 Receptor - Gqa fusion protein
  • Protein length
    Full length protein
  • Description
    Recombinant Human Histamine H2 Receptor - Gqα fusion protein

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human
    • Additional sequence information
      Tagged at the N terminus of the Histamine H2 Receptor with a DDDDK tag. The C terminus of the Histamine H2 Receptor is linked to the N terminus of the Gq alpha with a His tag.

Specifications

Our Abpromise guarantee covers the use of ab90397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

General Info

  • Alternative names
    • 1110005L02Rik
    • 6230401I02Rik
    • AA408290
    • AW060788
    • Dsk1
    • Dsk10
    • G alpha q
    • Galphaq
    • GAQ
    • Gastric receptor I
    • GNAQ
    • Gq
    • GqI
    • Guanine nucleotide binding protein (G protein) q polypeptide
    • Guanine nucleotide binding protein alpha q
    • Guanine nucleotide binding protein G(q) subunit alpha
    • H2R
    • Heterotrimeric guanine nucleotide-binding protein alpha q subunit
    • Histamine receptor H2
    • HRH2
    • OTTHUMP00000161242
    see all
  • Relevance
    Histamine H2 Receptor belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Guanine nucleotide-binding proteins (G proteins) are a family of heterotrimeric proteins that couple cell surface, G protein-coupled receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. Gq alpha is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta.
  • Cellular localization
    Histamine H2 Receptor: Cell membrane; Multi-pass membrane protein.

References

ab90397 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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