Recombinant Human Histamine H2 Receptor + GsaL fusion protein (ab90398)

Overview

  • Product name
    Recombinant Human Histamine H2 Receptor + GsaL fusion protein
  • Protein length
    Full length protein
  • Description
    Recombinant Human Histamine H2 Receptor + GsαL fusion protein

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      90 kDa including tags
    • Additional sequence information
      Tagged at the N terminus of the Histamine H2 Receptor with a DDDDK tag. The C terminus of the Histamine H2 Receptor is linked to the N terminus of the Gs alpha L with a His tag.

Specifications

Our Abpromise guarantee covers the use of ab90398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

General Info

  • Alternative names
    • Adenylate cyclase-stimulating G alpha protein
    • AHO
    • Alpha S long
    • Alpha S2
    • C20orf45
    • Gastric receptor 1
    • GNAS complex locus
    • GNAS1
    • GNASl
    • GPSA
    • GSA
    • GSP
    • Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    • H2R
    • HGNC:5183
    • Histamine H2 receptor
    • Histamine receptor H2
    • MGC33735
    • NESP
    • PHP1A
    • PHP1B
    • POH
    see all
  • Relevance
    The H2 subclass of histamine receptors mediates gastric acid secretion. It also appears to regulate gastrointestinal motility and intestinal secretion. HRH2 has a possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined.
  • Cellular localization
    Histamine H2 Receptor: Cell membrane; Multi-pass membrane protein.

References

ab90398 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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