High mobility group (nonhistone chromosomal) protein 2
High mobility group box 2
High mobility group protein 2
High mobility group protein B2
FunctionDNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS).
Sequence similaritiesBelongs to the HMGB family. Contains 2 HMG box DNA-binding domains.