Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMPKRKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTS AKKEPGAKIS RGAKGKKEEK QEAGKEGTEN
    • Molecular weight
      11 kDa including tags
    • Amino acids
      1 to 77
    • Tags
      His tag N-Terminus
    • Additional sequence information
      NP_620058

Specifications

Our Abpromise guarantee covers the use of ab183234 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >95% by SDS-PAGE .
    ab183234 was purified using conventional chromatography.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.00
    Constituents: 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • DKFZp686E20226
    • FLJ42187
    • High mobility group nucleosomal binding domain 3
    • High mobility group nucleosome-binding domain-containing protein 3
    • HMGN3
    • HMGN3_HUMAN
    • OTTHUMP00000016772
    • OTTHUMP00000016773
    • PNAS 24
    • PNAS 25
    • PNAS24
    • PNAS25
    • Thyroid hormone receptor interacting protein 7
    • Thyroid receptor-interacting protein 7
    • TR-interacting protein 7
    • TRIP 7
    • TRIP-7
    • TRIP7
    see all
  • Function
    Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
  • Tissue specificity
    Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.
  • Sequence similarities
    Belongs to the HMGN family.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab183234 (3µg)

References

ab183234 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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